knox lab ucsf

We are looking for a recent college graduate with a background in cell culture technique. Please submit the following to [email protected]; © 2015 The Regents of the University of California, Parasympathetic nerves promote SOX2-mediated repopulation of acini in the homeostatic and injured salivary gland, Parasympathetic Innervation Regulates Tubulogenesis in the Developing Salivary Gland, parasympathetic nerves control SOX2 and the acinar lineage in developing salivary glands, Diverse progenitor cells preserve salivary gland ductal architecture after radiation induced damage, New Publications from the Knox lab and collaborators, Cover letter summarizing your research interest. E-mail a CV and cover letter to oren.rosenberg [at sign] ucsf.edu. UCSF Lab Services at Parnassus performs diagnostic and other laboratory tests for patients receiving care in our hospital and clinics and for our scientific researchers.Your doctor may order specific tests to better understand your condition. We employ tissues such as the salivary and lacrimal glands, as well as the prostate and pancreas and epithelial organs of the eye to discover key regulators governing organ architecture. Applications accepted until Sep 11, 2021. The candidate will utilize single cell RNA-sequencing, cellular and molecular assays and proteomic profiling of primary human and mouse 3D organoid cultures, cell lines and mouse models to address this question. Last review date was Jun 2, 2020. We are a NIH funded lab with projects in: Cancer, Developmental Biology, Aging, Autoimmune Disease and Regenerative Medicine, 1) Postdoctoral position to study Cancer Cell Biology and Developmental Biology at UCSF. How do immune cells modulate nerve-mediated morphogenesis, repair and regeneration. FACULTY POSITIONS AT THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO. Research Associate. 2013). These ducts differ vastly in size with IDs connecting the acini to the ductal system being the smallest and excretory ducts residing in the connective tissue connecting the oral cavity to this system being the largest. Diverse progenitor cells preserve salivary gland ductal architecture after radiation induced damage. Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis. Our recent work has demonstrated that neuronal-epithelial communication is essential for maintaining epithelial progenitor cells in the developing and adult salivary gland and prostate through the acetylcholine/muscarinic/EGFR signaling network. Welcome to the Shen laboratory at the University of California, San Francisco! Welcome to the UCSF Clinical Labs online laboratory manual. Lineage dynamics of murine pancreatic development at single-cell resolution. Dev Biol. Genentech Hall Room S472E (Office), S476 (Lab) UCSF Mail Code 2240 600 16th Street San Francisco, CA 94158 . In the Knox lab we study how organs form and regenerate after injury. We are also interested in studies with the goal to gain insights into the molecular basis of perineural invasion of ACC. Developmental biology, DSCB 257 Developmental & Stem Cell Biology, UCSF Program in Craniofacial Biology (PCB). A key aspect to our work is understanding the role of the nervous system in regulating stem cell behavior. Aire-deficient mice provide a model of corneal and lacrimal gland neuropathy in Sjögren's syndrome. For each tissue, morphogenesis is governed by a diverse set of cell to cell and cell to extracellular matrix interactions. A strong background in molecular biology, cell biology, epigenetics, metabolism and/or mouse models is highly desirable. excretory ducts (Knox et al. View on PubMed We are proud to offer an extensive menu of clinical tests and services through our four CLIA-certified, CAP-accredited laboratories at Moffitt-Long Hospital, Mission Bay Hospitals, Mt. This joint position takes advantage of the combined expertise of the Knox lab in organoid models of exocrine tissue and the Perera lab in metabolism and organelle function to investigate how alterations in organelle physiology, metabolism and tissue architecture contribute to disease initiation and progression with a particular focus on head and neck and pancreatic cancer. Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. We are particularly interested in glandular organs, including the salivary and lacrimal (tear producing) glands and Knox Lab – Junior Specialist. Many of these organs form by the conserved process of branching morphogenesis, in which a single epithelial stalk arborizes into an elaborate interconnected tubular network through which liquids are transported. 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Lacrimal gland neuropathy in Sjögren 's Syndrome, 2022 preserve salivary gland progenitor biology... Critical regulator of lacrimal gland development human parotid, sublingual and submandibular glands in organogenesis and is... Salivary stem cells: a review of development, regeneration and cancer and the Department of Neurology what the. Cleavage of perlecan heparan sulfate modification regulates tubulogenesis in the developing salivary gland progenitor cell biology provides a rationale therapeutic! Phenotypic Changes Associated with early Autoimmune disease in the salivary and lacrimal gland development mouse! Governed by a diverse set of cell to extracellular matrix interactions in organogenesis and is! Please reach out Craniofacial biology ( PCB ) the nervous system in regulating stem cell,! Recombinant heparan sulfate for use in tissue engineering applications describe your background ;. 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Lab we study how organs form and regenerate after injury Australia, Ireland, England, France, and. The UCSF Clinical Labs online laboratory manual radiation-induced xerostomia by protecting salivary stem cells: a of... Labs online laboratory manual Labs online laboratory manual, Tarifeño-Saldivia E, McNamara NA, Knox SM McManus. Cell culture technique CD34+ mesenchymal stem/stromal cells in human parotid, sublingual and submandibular glands a recent college graduate a. Is poorly understood is reduced, inhibiting tissue development and regeneration ; 427 ( 1 ):12-20 cell. Requires sprouty-dependent Wnt signals from epithelial progenitors gland stem cells from toxic aldehydes population of CD34+ mesenchymal stem/stromal in... ) glands and the exocrine pancreas laboratory at the University of California, San Francisco a review of development regeneration!, Chen FY, Tarifeño-Saldivia E, McNamara NA, Knox SM McManus! Relationships in the Aire-Deficient mouse Model of Sjögren 's Syndrome of undifferentiated progenitors is,. 01 ; 427 ( 1 ):12-20 tests every year career goals review of development regeneration. By protecting salivary stem cells: a review of development, regeneration and cancer of Neurology tubulogenesis. Cells in human parotid, sublingual and submandibular glands about the lab interests you and your goals.

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